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Subject: New Scientist
Date: Thu, 19 Jun 2003 11:33:11 +0200
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            <P><B class=3Dnewsarthead>Toxic metal clue to autism</B> =
</P></TD></TR>
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          <TD align=3Dleft><SMALL=20
            =
class=3Dblu>19:00&nbsp;18&nbsp;June&nbsp;03</SMALL></TD></TR>
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        <TR>
          <TD><SMALL class=3Dred>Exclusive from New Scientist <A =
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            <P>A study of mercury levels in the baby hair of children =
who were=20
            later diagnosed with autism has produced startling results. =
The=20
            babies had far lower levels of mercury in their hair than =
other=20
            infants, leading to speculation that autistic children =
either do not=20
            absorb mercury or, more likely, cannot excrete it.</P>
            <P>The results will be seized upon by parents who blame =
vaccines=20
            containing the mercury-based preservative thimerosal for =
their=20
            children's autism, some of whom are suing health authorities =
in the=20
            US and Canada. (The MMR vaccine that some accuse of =
triggering=20
            autism, despite a lack of credible evidence, does not =
contain=20
            mercury.) </P>
            <P>But while the study's findings support the theory that =
some=20
            children have a genetic fault that makes them far more =
susceptible=20
            to mercury poisoning, the results certainly do not prove =
this, or=20
            that thimerosal is involved. </P>
            <P>The difference in mercury levels in hair may be a sign of =
a more=20
            general problem in dealing with metals or it could simply be =
an=20
            anomaly that reveals little about what is happening =
elsewhere in the=20
            body. </P>
            <P>But if the results are confirmed, the conclusions of =
studies=20
            looking at the safety of low levels of mercury (<B>New =
Scientist</B>=20
            print edition, 14 June) could also be called into question. =
Many of=20
            these studies relied on mercury levels in hair as a measure =
of=20
            exposure.</P>
            <P><BR><B class=3Dnewscrosshead>First cuttings</B> <BR></P>
            <P>Autism experts say the findings are intriguing, but all =
emphasise=20
            the need for further studies. Although the findings are to =
be=20
            published in a peer-reviewed journal, some critics say the =
results=20
            are rather too striking, and point out that the researchers =
who did=20
            the work all believe that thimerosal is to blame for =
autism.</P>
            <P>The team leader, Louisiana doctor Amy Holmes, in fact set =
out to=20
            try to prove that autistic children had been exposed to high =
levels=20
            of mercury. She obtained baby hair from parents who had kept =
the=20
            first cuttings and sent off a few samples for analysis. To =
her=20
            surprise, mercury levels were low.</P>
            <P>Holmes has now done a bigger study, comparing mercury =
levels in=20
            first baby haircuts from 94 autistic children with those of =
45 other=20
            children. The mean level in the baby hair of children later=20
            diagnosed as autistic was 0.47 parts per million, compared =
with 3.63=20
            ppm in the others, the team found - nearly nine-tenths =
lower. </P>
            <P>What is more, the more severe the autism, the lower the =
mercury=20
            levels. The mean levels of children with mild, moderate and =
severe=20
            autism were 0.79, 0.46 and 0.21 ppm respectively.</P>
            <P><BR><B class=3Dnewscrosshead>Fillings and fish</B> =
<BR></P>
            <P>Most of this mercury came from the mothers. The main =
sources of=20
            exposure, according to the team, were mercury amalgam =
fillings, Rho=20
            D immunoglobulin injections containing thimerosal given to =
Rhesus=20
            negative mothers, and heavy consumption of fish (defined as =
more=20
            than five fish meals a month). </P>
            <P>In the control group, hair mercury rose in line with the =
mothers'=20
            exposure. But the baby hair of autistic children had =
consistently=20
            low mercury levels, even when the mothers' exposure was =
high, the=20
            team found. The results will appear in the <I>International =
Journal=20
            of Toxicology</I> in September.</P>
            <P>One explanation, says team member Mark Blaxill of the =
campaign=20
            group SafeMinds of Cambridge, Massachusetts, is a problem =
with metal=20
            uptake. If so, autistic children might also be deficient in =
metals=20
            essential for brain development such as zinc, iron and =
copper.</P>
            <P>Alternatively, some children may have a problem excreting =

            mercury. The metal might then build up in the brain, =
producing=20
            autism. Most mercury is excreted in urine and faeces, but =
the lack=20
            of mercury in hair might be a sign that the metal is being =
retained=20
            in cells rather than getting into the blood, the researchers =

            suggest.</P>
            <P>Mercury is one of the suspected causes of autism, with =
proponents=20
            arguing that there are many similarities between autism and =
mercury=20
            poisoning. But a review published earlier in 2003 pointed =
out that=20
            poisoning by the different forms of mercury found in fish, =
fillings=20
            and thimerosal has effects distinct from autism, and =
concluded that=20
            what little evidence there is does not support any link.</P>
            <P><BR><B class=3Dnewscrosshead>'Loaded to the gills'</B> =
<BR></P>
            <P>Despite this, some doctors, including Holmes, have been=20
            experimenting with giving autistic children metal-binding =
agents, or=20
            chelators, to rid the body of heavy metals. "They are loaded =
to the=20
            gills with metals," Holmes, who was unavailable for comment, =
claimed=20
            in 2002. The only published evidence, however, is a very =
small study=20
            from 1976 suggesting autistic children have higher levels of =
lead in=20
            their blood.</P>
            <P>Critics such as child neurologist Emanuel Dicicco-Bloom =
of the=20
            Robert Wood Johnson Medical School in New Jersey says =
concluding=20
            that autistic children accumulate mercury on the basis of =
low levels=20
            in hair is a big logical leap that is not justified by the=20
            evidence.</P>
            <P>Even some of those who blame heavy metals such as mercury =
for=20
            autism echo his warnings not to try potentially dangerous =
therapies=20
            such as chelation. Parents should wait for the results of =
the=20
            clinical trials about to begin, they say. </P>
            <P>And Dicicco-Bloom's colleague Mike Gochfield, who does =
mercury=20
            testing, says that the levels of mercury in the control =
group are=20
            way above what he would expect for children in the US. =
Blaxill's=20
            response is that no one has ever tested first baby haircuts =
before,=20
            so there are no "normal" results to compare to. </P>
            <P>The lab that did the testing was not told which children =
the=20
            samples were from, he adds. And according to unpublished =
work by=20
            Steve Lindow and Steve Haslow at the University of Hull in =
the UK,=20
            hair mercury levels in newborns can be even higher than in =
the=20
            mother. </P>
            <TABLE cellSpacing=3D0 cellPadding=3D0 width=3D195 =
align=3Dright=20
            bgColor=3D#ffffff border=3D0>
              <TBODY>
              <TR>
                <TD class=3Dspace5>&nbsp;</TD></TR>
              <TR class=3Dboxheader>
                <TD align=3Dleft><IMG height=3D15 alt=3D"More on this =
story"=20
                  hspace=3D0=20
                  =
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                  width=3D195 border=3D0></TD></TR>
              <TR>
                <TD class=3Dspace5>&nbsp;</TD></TR>
              <TR>
                <TD align=3Dleft>
                  <DIV class=3Dleftmarg>
                  <P><B class=3Dnewscrosshead>Related Stories</B> =
</P></DIV></TD></TR>
              <TR>
                <TD class=3Dspace5>&nbsp;</TD></TR>
              <TR>
                <TD>
                  <DIV class=3Dleftmarg><SMALL><A=20
                  =
href=3D"http://www.newscientist.com/news/news.jsp?id=3Dns99993742"=20
                  target=3D_self>British public "duped" over MMR fears =
</A><BR=20
                  clear=3Dleft>19 May 2003</SMALL> </DIV></TD></TR>
              <TR>
                <TD class=3Dspace5>&nbsp;</TD></TR>
              <TR>
                <TD>
                  <DIV class=3Dleftmarg><SMALL><A=20
                  =
href=3D"http://www.newscientist.com/news/news.jsp?id=3Dns99993196"=20
                  target=3D_self>Danger of toxic metals in soils =
underestimated=20
                  </A><BR clear=3Dleft>23 December 2002</SMALL> =
</DIV></TD></TR>
              <TR>
                <TD class=3Dspace5>&nbsp;</TD></TR>
              <TR>
                <TD>
                  <DIV class=3Dleftmarg><SMALL><A=20
                  =
href=3D"http://www.newscientist.com/news/news.jsp?id=3Dns99993028"=20
                  target=3D_self>MMR and autism not linked, finds giant =
study=20
                  </A><BR clear=3Dleft>7 November 2002</SMALL> =
</DIV></TD></TR>
              <TR>
                <TD class=3Dspace5>&nbsp;</TD></TR>
              <TR>
                <TD class=3Dspace8>&nbsp;</TD></TR>
              <TR>
                <TD align=3Dleft>
                  <DIV class=3Dleftmarg><SMALL>For more related stories=20
                  <BR><B>search the print edition <A=20
                  =
href=3D"http://archive.newscientist.com/">Archive</A></B></SMALL>=20
                  </DIV></TD></TR>
              <TR>
                <TD class=3Dspace5>&nbsp;</TD></TR>
              <TR>
                <TD class=3Dboxheader><IMG height=3D1 alt=3D""=20
                  src=3D"http://www.newscientist.com/img/shim.gif" =
width=3D1=20
                  border=3D0></TD></TR>
              <TR>
                <TD class=3Dspace5>&nbsp;</TD></TR>
              <TR>
                <TD align=3Dleft>
                  <DIV class=3Dleftmarg>
                  <P><B class=3Dnewscrosshead>Weblinks</B> =
</P></DIV></TD></TR>
              <TR>
                <TD class=3Dspace5>&nbsp;</TD></TR>
              <TR>
                <TD align=3Dleft>
                  <DIV class=3Dleftmarg><SMALL><A =
href=3D"http://www.safeminds.org/"=20
                  target=3Dns>SafeMinds</A></SMALL> </DIV></TD></TR>
              <TR>
                <TD class=3Dspace5>&nbsp;</TD></TR>
              <TR>
                <TD align=3Dleft>
                  <DIV class=3Dleftmarg><SMALL><A=20
                  =
href=3D"http://www.cdc.gov/nip/vacsafe/concerns/thimerosal/default.htm"=20
                  target=3Dns>Thimerosal, US Centers for Disease Control =
and=20
                  Prevention</A></SMALL> </DIV></TD></TR>
              <TR>
                <TD class=3Dspace5>&nbsp;</TD></TR>
              <TR>
                <TD align=3Dleft>
                  <DIV class=3Dleftmarg><SMALL><A=20
                  =
href=3D"http://www.hull.ac.uk/chemistry/analyticalscience/stephenhaswell.=
html"=20
                  target=3Dns>Stephen Haswell, University of =
Hull</A></SMALL>=20
                  </DIV></TD></TR>
              <TR>
                <TD class=3Dspace5>&nbsp;</TD></TR>
              <TR>
                <TD align=3Dleft>
                  <DIV class=3Dleftmarg><SMALL><A =
href=3D"http://www.jabs.org.uk/"=20
                  target=3Dns>JABS</A></SMALL> </DIV></TD></TR>
              <TR>
                <TD class=3Dspace5>&nbsp;</TD></TR>
              <TR>
                <TD align=3Dleft>
                  <DIV class=3Dleftmarg><SMALL><A=20
                  href=3D"http://www.actox.org/journal.htm"=20
                  target=3Dns>International Journal of =
Toxicology</A></SMALL>=20
                  </DIV></TD></TR>
              <TR>
                <TD class=3Dspace5>&nbsp;</TD></TR>
              <TR>
                <TD class=3Dboxheader><IMG height=3D1 alt=3D""=20
                  src=3D"http://www.newscientist.com/img/shim.gif" =
width=3D1=20
                  border=3D0></TD></TR>
              <TR>
                <TD class=3Dspace8>&nbsp;</TD></TR></TBODY></TABLE>
            <P><BR><B class=3Dnewscrosshead>Active transport</B> =
<BR></P>
            <P>They suspect that mothers may actively transport metals =
to the=20
            fetus. But on average the first baby hair in Holmes' study =
was cut=20
            at 18 months old, so this would not explain the high levels =
in the=20
            controls.</P>
            <P>Astonishingly, only one other published study, from 1985, =
has=20
            compared mercury levels in the hair of children with and =
without=20
            autism. That study found no difference, but it did find =
lower levels=20
            of metals such as calcium, copper and chromium - levels that =
were so=20
            distinctive they could be used as a "diagnostic tool for =
autism".=20
            </P>
            <P>Other experts say the theory that autistic children are=20
            particularly at risk from heavy metals is at least =
plausible. "This=20
            kind of gene-environment interaction is not incompatible =
with the=20
            known heritability of autism," says Simon Baron-Cohen of =
Cambridge=20
            University. "If these results hold up, metal studies on the =
brain=20
            could be revealing." </P></TD></TR>
        <TR>
          <TD class=3Dspace8 align=3Dleft>&nbsp;</TD></TR>
        <TR>
          <TD>
            <P class=3Dblu>Richard Lathe and Michael Le =
Page</P></TD></TR>
        <TR>
          <TD><BR clear=3Dleft>
            <P>For more exclusive news and expert analysis every week =
<B><A=20
            =
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