PET Synthesis Applications

Coherent Synthesis technology reduces reaction times for radio labelling reactions requiring high temperatures. Consequently, the efficiency of these reactions is drastically improved. The following table shows yields and reaction times using thermal heating, ordinary microwaves and Coherent Synthesis

Aromatic radiofluorinations

		Thermal Heating			Ordinary Microwave		Coherent Synthesis
X	R	Y(%)	T(oC)	Time (min)	Y(%)	Time (min)	Y(%)	Time (min)
NO2	2-CHO	78	120	10	65	2	76	0.25
NO2	4-CHO	70	85-110	20	65	2	75	0.5
NO2	4-CN	40-70	150	10	68	3	65	0.5
NO2	2-CN	65	150	15			74	0.5
Br	4-CHO	3	85-110	20			7-13	0.5-1.5

X=Leaving Group, R=Activating Group, Ref: Stone-Elander, S.A. & Elander, N.
Appl. Radiat. Isot. Vol 44, No.5, pp889-893 (1993)

Contactable Users of Labwell instruments

PET Chemistry

• Professor Jerry Nickles, Dept. of Medical Physics, University of Wisconsin-Madison.
• Mr. S.P. Tilkema, Groningen University Hospital.
• Dr. Chester Mathis, Pittsburgh University Medical School.
• Dr. N. Satyamurthy, Dept. of Molecular and Medical Pharmacology, UCLA School of Medicine.

Back to LabWell homepage